Restriction of dietary has often proven to be the best method to reduce aging processes and prolong a person’s lifespan. Calorie restriction (CR) and Dietary restriction (DR) have been interchangeable applied by medical practitioners to describe the reduction of energy intake. DR means reducing the amount of food intake while CR implies decreasing a diet’s energy density by modifying dietary composition. Therefore, DR is more laborious to achieve compared to CR.
Tests indicate that the periods of fasting that occur in DR regimens affect the lifespan-extending effects because a substantial decrease in the energy density fails to prolong lifespan. Furthermore, the deactivation of significant nutrient sensing anabolic pathways called mTOR during the fasting periods affects the production of lifespan-extending effects. The mechanistic target of rapamycin, mTOR, counteracts cellular rejuvenation through hindering autophagy and promoting metabolic derangement including insulin receptors. Further, mTORhyperactivation due to constant circulation of nutrients causes cellular senescence and aging. Overeating or ad libitum (AL) is likely to promote the aging phenotype. A reduction in the AL effects including obesity has proven to have an anti-aging potential in the following: http://endnote.com/downloads/style/oncotarget click here.
Cellular rejuvenation enhanced by a response to DR through an experiment involving the induction of a chaperone mediated autophagy to AL mice. Another experiment involved applying a nutritional approach to investigate the effect of the dietary macronutrient composition on a person’s lifespan. The results revealed that postponement of sexual reproduction was responsible for DR-related longevity.
An Overview of Oncotarget
Oncotarget is a leading medical journal that publishes research papers online on a weekly basis. These journals have free-access to all people and comprise of all aspect of oncology. Further, Oncotarget’s mission is to enhance the spread of scientific outcomes thus maximizing the impact of the research through perceptive reviews. It also aims to reduce the boundary between different medical specialties and link the field of biomedical science.
Additionally, these journals foster the application of both clinical and basics sciences to protect people from diseases. Oncotarget is helpful to researchers who gain knowledge that enables them to continue with their contribution to science. Mikhail Blagosklonny is one of the talented editors-in-chief of Oncotarget.